It has always been thought that we are just plain old human beings being composed of mere human eukaryotic cells and occasionally attacked by viruses and bacteria. But this vision is plainly wrong. We now know that we are a coherent mix of all kinds of life, running from unicellular microorganisms to pluricellular organisms, which form part and parcel of what can be called human being. We are “holobionts” and as such the multiplicity of cells and viruses belonging to all kingdoms of life collaborate in an equilibrium that if perturbed can cause disease. The ancient medicines (including Western Constitutional Medicine [WCM]) adopted this way of thinking and the ancient observers sagely imprinted their medicinal systems with this holistic view of life for which disease has to be contrasted with a return to equilibrium. And the ancient medicines used as primary tool the correction of the diet seen as the restoration of the equilibrium between the energies (microorganisms) in the body. More recently a new medicinal system the ABO groups has taken a stronger stand in the scientific arena through the experimental confirmation of its main mechanism of action by glycosciences (especially glycobiology). Necessarily, bacteria, fungi and other unicellular organisms can feed off on glycans which are both produced and absorbed by the human body (diet) and the suitable balance of diet will interfere in this cycle. It is now the time to capture all these advances in ancient and modern medicine and fuse them into a new medicinal system, the ABO-WCM biotypology, to better explain the reality of the holobiont and to completely transform modern science into a truly personalized approach.