Vol. 5, Issue 2, Part A (2023)

Background: The pro-adrenomeduline central region (MR-proADM) and biochemical parameters perform many biological activities throughout the human body. Thus, an increase in their level in plasma and blood is directly associated with an increased risk of developing type 2 diabetes mellitus (T₂ DM). However, the potential association between MR-proADM and biochemical parameters in patients with T₂ DM is still not well understood and studies in this area are limited. The present study aimed to assessment the relationship between MR-proADM and biochemical parameters and its association with T₂ DM in the population of Kirkuk, Iraq. 
Methods: The current cross-sectional study included a total of 90 participants (55 with T₂ DM and 45 healthy without T₂ DM) and all of them underwent several important routine health examinations. The patients' ages ranged from 19 to 34 years. The samples were collected for the measurement of MR-proADM and biochemical parameters by biochemical and clinical measurement methods specified in this study. The association between MR-proADM and biochemical parameters in T₂ DM was evaluated by statistical analysis methods represented by SPSS version 20, and the associations for these variables were found by Pearson's correlation. 
Results: The mean value of glucose, Alkaline phosphatase (ALP) and MR-proADM for participants with T2DM was significantly higher (P = 0.007), (P = 0.020), and (P =0.005) compared to the control group. While the mean value of total serum bilirubin of the participants with T₂ DM was low and significantly uncorrelated (P = 0.457) respectively compared to the control group. The mean value of calcium and vitamin D of participants with T₂ DM was low but significantly associated (P = 0.031) and (P = 0.029) respectively compared to control group. Regarding MR-proADM values and biochemical parameters in T₂ DM, found that MR-proADM was positively correlated with blood glucose levels and ALP in T₂ DM patients and negatively correlated with vitamin D. While there was no correlation between MR-proADM and serum bilirubin and calcium in T₂ DM patients. 
Conclusions: Elevated levels of blood glucose, ALP and MR-proADM were observed in patients with T₂ DM, and it was found that there is a correlation between MR-proADM and biochemical parameters of T₂ DM. This study recommend testing and screening for MR-proADM and biochemical parameters on a larger scale as it has been shown to be associated with type 2 diabetes.