Vol. 6, Issue 2, Part A (2024)

Gene amplification is a critical genetic phenomenon involved in the adaptation and evolution of various organisms, including microorganisms and humans. This study investigates the genetic pathways underlying gene amplification using the soil bacterium Acinetobacter baylyi as a model organism. The research focuses on identifying specific genes, such as MGD18 and ACIAD0692, that contribute to the formation of gene amplification mutations. By constructing site-specific mutants and employing molecular biology techniques, the study aims to elucidate the roles of these genes in gene amplification. The findings have significant implications for understanding gene amplification's role in cancer and infectious diseases, potentially paving the way for therapeutic interventions to inhibit gene amplification and prevent disease progression.