Vol. 7, Issue 2, Part A (2025)

Antimicrobial resistance (AMR) is a rapidly growing emerging health problem worldwide due to its ability to reduce the effectiveness of conventional antibiotics and complicate their use. The medicinal fungi (used traditionally in the treatment of some diseases) are known to produce a broad spectrum of biologically active compounds with anti-inflammatory, immunomodulatory, and antimicrobial effects. Recent research has shown that the fungi can be used as substitutes or addition to traditional antibiotics to increase efficacy or counteract the resistant strains. This review was used to analyze the antimicrobial action of medicinal fungi, its clinical use, combinations with antibiotics, and difficulties in standardization and clinical translation. Medicinal fungi are a potentially promising strategy to overcome antibiotic resistance through the incorporation of their therapeutic uses.